Antimicrobial
Cationic peptides with broad-spectrum antibacterial, antifungal, and antiviral activity through membrane disruption.
6 peptides in this category
LL-37
LL-37 is a 37-amino acid cationic antimicrobial peptide (AMP), the only known member of the cathelicidin family in humans. It is generated by proteolytic cleava...
Extensive preclinical research. Some clinical exploration for wound healing andDefensin HNP-1
HNP-1 (Human Neutrophil Peptide-1) is a 30-amino acid cationic alpha-defensin stored in the azurophilic granules of human neutrophils and released during phagoc...
Extensively characterized in vitro. Used as research tool for antimicrobial peptMagainin-2
Magainin-2 is a 23-amino acid amphipathic alpha-helical antimicrobial peptide first isolated from the skin of the African clawed frog Xenopus laevis by Michael ...
Foundational research peptide. MSI-78 (pexiganan), a magainin analog, reached PhNisin
Nisin is a 34-amino acid polycyclic antimicrobial lantibiotic peptide produced by Lactococcus lactis that has been used as a food preservative for over six deca...
GRAS food preservative since 1988. Clinical development ongoing for MRSA, C. difGE2270A
GE2270A is a thiopeptide antibiotic produced by Planobispora rosea that inhibits bacterial translation by targeting elongation factor Tu (EF-Tu). It represents ...
Preclinical. Research tool compound. Synthetic derivative programs ongoing to imEnfuvirtide (T-20)
Enfuvirtide (Fuzeon) is a synthetic 36-amino acid peptide HIV fusion inhibitor that was the first member of this antiretroviral drug class and remains the only ...
FDA-approved 2003. Standard of care for multidrug-resistant HIV. High injection