Pain & Inflammation
Peptides with anti-inflammatory, analgesic, or immune-modulating properties relevant to pain management.
17 peptides in this category
BPC-157
BPC-157 is a synthetic 15-amino acid peptide derived from a naturally occurring protective protein isolated from human gastric juice. Originally characterized b...
Extensive preclinical (in vitro and rodent in vivo) data. Multiple Phase I/II clTB-500
TB-500 is a synthetic heptapeptide corresponding to the N-acetylated active fragment (amino acids 17–23) of the endogenous 43-amino acid signaling protein thymo...
Extensive animal model data. TB-500 is classified as a prohibited substance by WSelank
Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on a fragment of immunoglobu...
Registered as a drug in Russia. Extensive Russian clinical and preclinical literDSIP
Delta Sleep-Inducing Peptide (DSIP) is a natural nonapeptide originally isolated from rabbit cerebrospinal fluid in 1977. It was initially characterized for its...
Preclinical and limited clinical research. Studies in insomnia, chronic pain, anVasoactive Intestinal Peptide
Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino acid neuropeptide found in the nervous system and immune cells throughout the body. It act...
Extensive preclinical data. Limited clinical trials for inflammatory conditions.Substance P
Substance P is an 11-amino acid neuropeptide belonging to the tachykinin family, functioning as a key neurotransmitter and neuromodulator involved in pain signa...
Extensively studied. NK1 antagonists (aprepitant) FDA-approved for chemotherapyKPV
KPV (Lys-Pro-Val) is the C-terminal active tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH). It retains the anti-inflammatory and cytoprotect...
Preclinical data primarily. Research phase for IBD and wound healing. No FDA-appSomatostatin
Somatostatin is a naturally occurring cyclic 14-amino acid neuropeptide (with an alternate 28-amino acid form) produced in the hypothalamus, pancreas, and gastr...
Parent compound of a major therapeutic drug class. Somatostatin itself is used sKPV
KPV is a tripeptide (Lys-Pro-Val) representing the C-terminal three amino acids of alpha-melanocyte stimulating hormone (α-MSH). It retains the anti-inflammator...
Preclinical. Colitis animal models show oral nanoparticle efficacy. No human triZiconotide
Ziconotide (Prialt) is a 25-amino acid synthetic equivalent of ω-conotoxin MVIIA, a peptide toxin from the cone snail Conus magus. FDA-approved in 2004 for seve...
FDA-approved 2004 (Prialt) for severe chronic pain via intrathecal administratioCGRP (Calcitonin Gene-Related Peptide)
Calcitonin Gene-Related Peptide (CGRP) is a 37-amino acid neuropeptide produced by alternative splicing of the calcitonin gene, expressed abundantly in trigemin...
CGRP itself: extensively characterized research peptide. Anti-CGRP antibodies: FCortistatin
Cortistatin is a neuropeptide related to somatostatin that is expressed predominantly in cortical interneurons. Unlike somatostatin, cortistatin binds with high...
Predominantly preclinical. Animal models of inflammatory disease show significanBNP (Brain Natriuretic Peptide) / Nesiritide
Brain Natriuretic Peptide (BNP) is a 32-amino acid cardiac-derived natriuretic peptide produced primarily by ventricular cardiomyocytes in response to increased...
FDA-approved 2001 (Nesiritide/Natrecor) for acute decompensated heart failure. LANP (Atrial Natriuretic Peptide)
Atrial Natriuretic Peptide (ANP) is a 28-amino acid peptide hormone released from cardiac atria in response to increased atrial pressure and volume overload. As...
ANP itself: research tool and endogenous biomarker. Carperitide (recombinant ANPTerlipressin
Terlipressin is a synthetic vasopressin analog and prodrug designed for selective splanchnic vasoconstriction with reduced systemic vasopressor effects compared...
FDA-approved 2022 (CONFIRM trial). EMA-approved for variceal bleeding since 2000Linaclotide
Linaclotide (Linzess/Constella) is a 14-amino acid synthetic peptide agonist of guanylate cyclase-C (GC-C) that is structurally derived from the heat-stable ent...
FDA-approved 2012 for CIC and IBS-C. Pediatric indication added 2017. ExtensiveCalcitonin
Calcitonin is a 32-amino acid peptide hormone produced by parafollicular C-cells of the thyroid gland in response to elevated serum calcium. It acts through cal...
FDA-approved. Multiple formulations (SC, IM, intranasal). Intranasal salmon calc