Growth Hormone Secretagogues
Peptides that stimulate the pituitary gland to release growth hormone, either by mimicking GHRH (GHRH analogs) or by acting on ghrelin receptors (GHRPs).
9 peptides in this category
CJC-1295
CJC-1295 is a 29-amino acid synthetic analog of growth hormone-releasing hormone (GHRH), structurally based on the first 29 amino acids of native GHRH with four...
Preclinical and Phase I/II human trials completed demonstrating GH/IGF-1 elevatiIpamorelin
Ipamorelin is a selective synthetic pentapeptide growth hormone secretagogue, developed as part of a major chemistry program targeting GHRP analogs. Unlike olde...
Well-characterized in preclinical and early clinical studies. Not FDA-approved aGHRP-6
GHRP-6 was one of the first synthetic growth hormone secretagogues discovered, derived from the structure of the endogenous opioid peptide met-enkephalin. It is...
Well-established in preclinical research. Not FDA-approved. Widely used as a resGHRP-2
GHRP-2 is a synthetic hexapeptide derived from met-enkephalin structure that functions as a potent GHS-R1a agonist. It is one of the most potent GHRPs in terms ...
Clinical trials completed for diagnostic use (approved in Japan as Pralmorelin).Sermorelin
Sermorelin is a synthetic 29-amino acid peptide that represents the shortest fully functional fragment of endogenous growth hormone-releasing hormone (GHRH). It...
FDA-approved historically (Geref) for pediatric GH deficiency diagnosis. CurrentTesamorelin
Tesamorelin is a synthetic stabilized analog of GHRH composed of the full 44-amino acid sequence of GHRH, conjugated with a trans-3-hexenoic acid modification t...
FDA-approved (Egrifta) for HIV-associated lipodystrophy. Active research ongoingHexarelin
Hexarelin is a synthetic hexapeptide member of the GHRP family with potent GH-releasing activity. It is unique among GHRPs for its demonstrated direct cardiovas...
Extensive preclinical data particularly for cardiovascular applications. Phase IMK-677 (Ibutamoren)
MK-677 (ibutamoren) is a potent, orally active, non-peptide GHS-R1a (ghrelin receptor) agonist that mimics ghrelin to stimulate pulsatile growth hormone secreti...
Multiple Phase II clinical trials completed. Not FDA-approved as a prescriptionGhrelin
Ghrelin is a 28-amino acid acylated peptide hormone produced primarily by X/A-like cells of the gastric fundus. It is the endogenous ligand for the growth hormo...
Characterized 1999 (Kojima et al.). Not used therapeutically as exogenous ghreli