GHRP-2
Also known as: Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102
Overview
GHRP-2 is a synthetic hexapeptide derived from met-enkephalin structure that functions as a potent GHS-R1a agonist. It is one of the most potent GHRPs in terms of GH release amplitude, capable of stimulating pulsatile GH secretion by over threefold compared to GHRH alone. GHRP-2 is approved in some countries for diagnostic testing of GH secretory capacity (as pralmorelin). It stimulates both GH and to a lesser extent ACTH and cortisol, making it less selective than ipamorelin.
Mechanism of Action
GHRP-2 activates GHS-R1a receptors with high affinity, triggering intracellular calcium signaling and protein kinase C activation in pituitary somatotrophs. This drives GH gene transcription and pulsatile GH secretion. Studies show it may stimulate anterior pituitary GH production up to 181 times baseline, with IGF-1 levels rising from ~100 to ~180 mcg/L. It also stimulates ghrelin release, appetite, and modest ACTH/cortisol elevation.
Potential Benefits
- Among the most potent GH-releasing peptides by amplitude
- IGF-1 elevation supporting muscle growth and recovery
- Pulsatile GH secretion mimicking physiological patterns
- Used as a diagnostic agent for GH deficiency evaluation
- Potential muscle hypertrophy and anti-atrophy effects
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 100-300 mcg/dose, 2-3x/day |
| Beginner | 100 mcg once daily at bedtime |
| Intermediate | 200 mcg twice daily |
| Advanced | 300 mcg 2-3x/day (morning, pre-workout, bedtime) |
| Cycle Duration | 6-8 weeks |
| Cycle Off | 4 weeks (to prevent tachyphylaxis) |
GHRP-2 is more potent than GHRP-6 but also stimulates cortisol and ACTH. Fasted state required for maximal GH response. Doses above 300 mcg do not increase GH output proportionally.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Subcutaneous Injection High
Primary route; inject fasted for maximal GH response; avoid dosing within 2 hours of carbohydrate or fat-containing meals
Intramuscular Injection High
Faster peak concentration; may enhance immediate post-workout GH response
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving GHRP-2:
Potent GH Stack
Maximum GH pulse amplitude for muscle growth
GHRP-2 combined with CJC-1295 can produce 54x normal pulsatile GH secretion in some studies; powerful but may moderately increase cortisol.
Diagnostic GH Protocol
Clinical GH secretory capacity assessment
GHRP-2 (Pralmorelin) is approved in Japan for GH deficiency diagnosis; combined with exogenous GHRH for definitive pituitary GH reserve assessment.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 5mg, 10mg |
|---|---|
| BAC Water | 2ml per 5mg vial |
| Storage | Refrigerate at 2-8°C after reconstitution |
| Shelf Life | 28 days refrigerated |
Need exact syringe measurements?
Amino Acid Sequence
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Side Effects & Safety
- Cortisol and ACTH elevation
- Appetite stimulation
- Water retention
- Flushing or warmth sensation
- Fatigue
Synergistic Compounds
The following compounds have been studied alongside GHRP-2 for potential complementary or synergistic effects:
Learn More
References & Further Reading
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