Cognitive & Nootropic
Peptides investigated for memory enhancement, focus, neuroprotection, and cognitive performance.
18 peptides in this category
BPC-157
BPC-157 is a synthetic 15-amino acid peptide derived from a naturally occurring protective protein isolated from human gastric juice. Originally characterized b...
Extensive preclinical (in vitro and rodent in vivo) data. Multiple Phase I/II clSelank
Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on a fragment of immunoglobu...
Registered as a drug in Russia. Extensive Russian clinical and preclinical literSemax
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) with an added Pro-Gly-Pro stabilizing tripeptide. Developed ...
Registered pharmaceutical in Russia. Extensive preclinical and Russian clinicalDihexa
Dihexa is a synthetic small peptide derived from angiotensin IV, developed at Washington State University as a hepatocyte growth factor (HGF) mimetic. It has de...
Preclinical data only (rodent models). Potent but no human clinical trials publiCerebrolysin
Cerebrolysin is a lipid-free neuropeptide preparation produced by standardized enzymatic breakdown of purified porcine brain proteins. The resulting mixture of ...
Approved drug in multiple countries (Europe, Asia) for stroke, TBI, dementia. NoP21
P21 (also called P021) is a synthetic tetrapeptide derived from the CNTF (ciliary neurotrophic factor) binding interface and designed to mimic neurotrophic sign...
Preclinical data primarily in cell culture and rodent models. Research ongoing aDavunetide
Davunetide (NAP, NAPVSIPQ) is an 8-amino acid neuroprotective peptide derived from the activity-dependent neuroprotective protein (ADNP). It was first identifie...
Phase II clinical trials completed for schizophrenia and PSP (progressive supranFGL
FGL is a 15-amino acid peptide synthesized from the interconnecting loop region of the second fibronectin type III module in the extracellular domain of the neu...
Phase I clinical trial completed for safety and pharmacokinetics. In clinical dePinealon
Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg) classified as a cytogen — a peptide that directly interacts with DNA to modulate gene expression r...
Preclinical and Russian clinical research. Developed by Khavinson's group in St.Cortagen
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) bioregulator developed by Professor Vladimir Khavinson based on amino acid analysis of cortexin, a polype...
Russian preclinical research primarily. Khavinson peptide family. Not FDA-approvOxytocin
Oxytocin is a 9-amino acid cyclic neuropeptide synthesized in the hypothalamus and released from the posterior pituitary. Colloquially known as the 'love hormon...
FDA-approved for obstetric use (Pitocin). Intranasal form under active Phase II/Cerebrolysin Peptide Fraction
Individual peptide fractions within Cerebrolysin preparation include components that mimic BDNF, GDNF, NGF, and CNTF activity. Research has identified specific ...
Research context primarily. Understanding of Cerebrolysin fractions guides peptiPACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)
PACAP is a 38-amino acid neuropeptide (with a shorter 27 AA form) belonging to the secretin/glucagon/VIP superfamily. It is one of the most potent known neuropr...
Extensive preclinical data. PAC1 receptor variants associated with PTSD susceptiNoopept
Noopept (GVS-111) is a synthetic dipeptide-derived nootropic compound that acts as a prodrug for cycloprolylglycine (CPG), an endogenous neuropeptide that modul...
Approved prescription medication in Russia for cognitive disorders. Research cheDihexa
Dihexa (PNB-0408) is a small hexapeptide derived from angiotensin IV that exhibits extraordinarily potent synaptogenic activity—reportedly 10 million times more...
Preclinical only. Human pharmacokinetics and safety not yet formally establishedNAP (Davunetide) Extended Notes
NAP (NAPVSIPQ) represents a critical bridge between VIP-based neuroprotection and practical clinical peptide therapeutics. The discovery that a single 8-amino a...
Phase II/III clinical trials completed for PSP (2012). Phase II for schizophreniCholecystokinin (CCK)
Cholecystokinin (CCK) is a peptide hormone found in multiple forms (CCK-8, CCK-33, CCK-58) secreted by enteroendocrine I-cells of the duodenum and jejunum in re...
Extensively characterized endogenous peptide. CCK analogs and CCK-1R agonists unPE-22-28
PE-22-28 is a synthetic pentapeptide analog of spadin, a naturally occurring peptide derived from the pro-region of the NTSR3/sortilin receptor. Spadin was iden...
Preclinical only (in vitro and rodent models). No human clinical trials yet comp