Overview
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) with an added Pro-Gly-Pro stabilizing tripeptide. Developed in Russia, it is registered as a pharmaceutical for cognitive enhancement, neuroprotection, and stroke recovery. Unlike Selank which primarily reduces anxiety, Semax has a stronger focus on neuroplasticity and cognitive performance through BDNF upregulation and dopaminergic enhancement. It is considered one of the most potent nootropic peptides in Russian pharmacology.
Mechanism of Action
Semax's primary mechanism involves upregulating brain-derived neurotrophic factor (BDNF) expression at both mRNA and protein levels, particularly in the hippocampus and cortex. It activates TrkB receptors and the downstream CREB transcription factor pathway, promoting neuroplasticity and synaptic strengthening. It also modulates dopaminergic neurotransmission, enhancing motivation and cognitive processing. Additional effects include neuroprotection against oxidative stress, anti-inflammatory properties, and stimulation of neurogenesis.
Potential Benefits
- BDNF upregulation promoting neuroplasticity and memory consolidation
- Enhanced focus, concentration, and analytical thinking
- Improved motivation and mental energy via dopamine modulation
- Neuroprotection against ischemic brain damage (stroke recovery use)
- Memory enhancement and faster learning
- Anti-inflammatory neuroprotective effects
- Registered drug in Russia for CNS ischemia and cognitive disorders
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 200-1000 mcg/day |
| Beginner | 200-300 mcg/day intranasally |
| Intermediate | 500-600 mcg/day |
| Advanced | 750-1000 mcg/day |
| Cycle Duration | 2-4 weeks; suited for acute cognitive tasks |
| Cycle Off | 2-4 weeks |
Administered intranasally (most common) or by injection. Nasal: 2-3 drops per nostril of appropriate concentration. BDNF-releasing properties suggest benefits accumulate over days. Often used in 2-4 week courses for cognitive enhancement or post-stroke neuroprotection.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Nasal Moderate
Most common and convenient route; rapid CNS access via olfactory pathway; 2-3 drops per nostril
Subcutaneous Injection High
Higher systemic bioavailability; used in neurological treatment protocols in Russia
Intramuscular Injection High
Used clinically in Russia and Eastern Europe for stroke rehabilitation
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving Semax:
Cognitive Enhancement Stack
Multi-pathway nootropic combining BDNF upregulation, anxiolysis, and synaptogenesis
Semax raises BDNF; Selank reduces anxiety without sedation; Dihexa drives new synapse formation. Comprehensive stack for cognitive performance.
Neurological Recovery Stack
Post-neurological injury rehabilitation support
Used in Eastern European clinical practice; Semax and Cerebrolysin have demonstrated post-stroke neuroprotective benefits; Epithalon adds anti-aging support.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 3mg, 10mg |
|---|---|
| BAC Water | 0.5-1ml per 3mg vial for injectable; nasal solution typically pre-formulated |
| Storage | Refrigerate nasal formulation at 2-8°C; injectable at 2-8°C after reconstitution |
| Shelf Life | 30 days refrigerated after reconstitution |
Need exact syringe measurements?
Amino Acid Sequence
Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-7 + Pro-Gly-Pro)
Side Effects & Safety
- Mild headache
- Nasal irritation with intranasal form
- Occasional overstimulation or anxiety at high doses
- Fatigue on discontinuation with prolonged use
Synergistic Compounds
The following compounds have been studied alongside Semax for potential complementary or synergistic effects:
Learn More
References & Further Reading
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