Selank
Also known as: Selanke, TP-7, Selank intranasal
Overview
Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on a fragment of immunoglobulin G (Thr-Lys-Pro-Arg-Pro-Gly-Pro) combined with a tuftsin fragment. Unlike classical anxiolytics, Selank reduces anxiety without sedation, making it suitable for daytime cognitive enhancement. It primarily influences GABAergic and serotonergic systems while also exhibiting neuroprotective and immune-modulating properties. It is registered as a medicine in Russia.
Mechanism of Action
Selank primarily modulates GABAergic neurotransmission and appears to alter expression of genes involved in GABA-related signaling. Electrophysiological studies show it increases inhibitory synaptic activity in hippocampal tissue. It modulates serotonin levels and serotonin receptor sensitivity, contributing to its anxiolytic and mood-stabilizing effects. It also influences BDNF expression and may have neuroimmune modulatory properties, affecting cytokine profiles in the CNS.
Potential Benefits
- Anxiety reduction without sedation or dependence
- Stress resilience and emotional stability
- Improved focus and cognitive clarity under stress
- Memory retention enhancement in stress-related cognitive impairment
- Immunomodulatory effects with potential neuroimmune benefits
- Anti-inflammatory neuroprotective activity
- No withdrawal effects or addiction potential
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 250-750 mcg/day intranasally |
| Beginner | 250 mcg/day (125 mcg each nostril) |
| Intermediate | 500 mcg/day |
| Advanced | 750 mcg/day |
| Cycle Duration | 2-4 weeks |
| Cycle Off | 2-4 weeks; well-tolerated for longer courses in Russian clinical practice |
Primarily used as intranasal spray. Anxiolytic effects are apparent within hours; cognitive benefits accumulate over days to weeks. Does not produce dependence or tolerance based on available research.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Nasal Moderate
Standard route; rapid CNS delivery via olfactory pathway; 125-250 mcg per nostril
Subcutaneous Injection High
Higher bioavailability; used in research protocols when systemic effects are targeted
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving Selank:
Anxiety + Cognition Stack
Combined anxiolysis and cognitive enhancement
Selank reduces anxiety and balances potential overstimulating effects of Semax while Semax drives BDNF upregulation and focus. Complementary mechanisms.
Immune + Anxiety Stack
Stress-related immune suppression reversal and anxiolysis
Selank normalizes IL-6 expression and anxiety; Thymosin Alpha-1 restores immune function compromised by chronic stress.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 5mg |
|---|---|
| BAC Water | Intranasal solution typically pre-formulated; injectable: 1-2ml per 5mg vial |
| Storage | Refrigerate at 2-8°C |
| Shelf Life | 30 days refrigerated after reconstitution |
Need exact syringe measurements?
Amino Acid Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (with tuftsin component)
Side Effects & Safety
- Generally well-tolerated
- Mild nasal irritation with intranasal formulation
- Slight sedation at high doses (uncommon)
- Rare fatigue or headache
Synergistic Compounds
The following compounds have been studied alongside Selank for potential complementary or synergistic effects:
Learn More
References & Further Reading
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