Selank
Also known as: Selanke, TP-7, Selank intranasal
Overview
Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on a fragment of immunoglobulin G (Thr-Lys-Pro-Arg-Pro-Gly-Pro) combined with a tuftsin fragment. Unlike classical anxiolytics, Selank reduces anxiety without sedation, making it suitable for daytime cognitive enhancement. It primarily influences GABAergic and serotonergic systems while also exhibiting neuroprotective and immune-modulating properties. It is registered as a medicine in Russia.
Mechanism of Action
Selank primarily modulates GABAergic neurotransmission and appears to alter expression of genes involved in GABA-related signaling. Electrophysiological studies show it increases inhibitory synaptic activity in hippocampal tissue. It modulates serotonin levels and serotonin receptor sensitivity, contributing to its anxiolytic and mood-stabilizing effects. It also influences BDNF expression and may have neuroimmune modulatory properties, affecting cytokine profiles in the CNS.
Potential Benefits
- Anxiety reduction without sedation or dependence
- Stress resilience and emotional stability
- Improved focus and cognitive clarity under stress
- Memory retention enhancement in stress-related cognitive impairment
- Immunomodulatory effects with potential neuroimmune benefits
- Anti-inflammatory neuroprotective activity
- No withdrawal effects or addiction potential
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 250-750 mcg/day intranasally |
| Beginner | 250 mcg/day (125 mcg each nostril) |
| Intermediate | 500 mcg/day |
| Advanced | 750 mcg/day |
| Cycle Duration | 2-4 weeks |
| Cycle Off | 2-4 weeks; well-tolerated for longer courses in Russian clinical practice |
Primarily used as intranasal spray. Anxiolytic effects are apparent within hours; cognitive benefits accumulate over days to weeks. Does not produce dependence or tolerance based on available research.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Intranasal High — direct CNS delivery via olfactory mucosa
Primary and preferred route. Typical dose 200–400 mcg, 2–3x daily. Provides anxiolytic effects within 15–30 minutes.
Subcutaneous Injection High — systemic and CNS effects
Alternative when nasal administration is impractical. Same dosing range.
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving Selank:
Anxiolytic Cognitive Stack
The classic Russian nootropic combination. Selank provides GABAergic anxiolysis and immune modulation while Semax enhances BDNF, dopamine, and cognitive function. Both administered intranasally.
Stress & Sleep Stack
Comprehensive stress and sleep support. Selank for daytime anxiety reduction, DSIP for delta sleep promotion and cortisol normalization, Semax for sustained cognitive clarity.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 5mg |
|---|---|
| BAC Water | Intranasal solution typically pre-formulated; injectable: 1-2ml per 5mg vial |
| Storage | Refrigerate at 2-8°C |
| Shelf Life | 30 days refrigerated after reconstitution |
Need exact syringe measurements?
Amino Acid Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (with tuftsin component)
Side Effects & Safety
- Generally well-tolerated
- Mild nasal irritation with intranasal formulation
- Slight sedation at high doses (uncommon)
- Rare fatigue or headache
Safety & Contraindications
This information is for educational purposes only. Consult a qualified healthcare provider before using any peptide.
Pregnancy / Lactation
Bleeding Disorders
Active Skin Infection at Injection Site
Drug Interactions
- CNS Depressants / Benzodiazepines:
FDA Safety Information
FDA Category 2 concerns: immunogenicity, no safety data.
Pharmacokinetics
| Half-Life | ~30 minutes (plasma); CNS effects persist hours |
|---|---|
| Storage | Store lyophilized peptide at -20°C (long-term) or 2-8°C (short-term, under 30 days). Reconstituted: refrigerate at 2-8°C and use within 28-30 days. Protect from light. Do not freeze reconstituted solution. |
Synergistic Compounds
The following compounds have been studied alongside Selank for potential complementary or synergistic effects:
Learn More
References & Further Reading
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