GHRP-6
Also known as: Growth Hormone Releasing Peptide-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Overview
GHRP-6 was one of the first synthetic growth hormone secretagogues discovered, derived from the structure of the endogenous opioid peptide met-enkephalin. It is a hexapeptide that acts as a potent ghrelin receptor agonist. Unlike ipamorelin, GHRP-6 stimulates both GH release and prolactin and cortisol to a moderate degree, and is known for strong appetite stimulation. It also shows cardioprotective properties through mechanisms partially distinct from GH release.
Mechanism of Action
GHRP-6 binds to GHS-R1a receptors in the pituitary and hypothalamus, stimulating GH secretion via the phospholipase C/PKC signaling pathway. It also activates GHRH neurons in the hypothalamus, augmenting the GHRH-driven component of GH release. Cardiac protective effects appear to involve sympathetic-to-parasympathetic switching and possible interactions with CD36 receptors in cardiac tissue. GHRP-6 may stimulate GH secretion up to 181-fold above baseline in some studies.
Potential Benefits
- Potent GH secretagogue with up to 181-fold GH increase in some studies
- Muscle hypertrophy support via GH/IGF-1 axis
- Cardioprotective effects through neuromodulation
- Appetite stimulation beneficial for muscle building protocols
- Anti-inflammatory properties in some models
- Enhanced wound healing at sub-GH secretagogue doses
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 100-300 mcg/dose, 2-3x/day |
| Beginner | 100 mcg once daily at bedtime |
| Intermediate | 200 mcg 2x/day |
| Advanced | 300 mcg 3x/day |
| Cycle Duration | 6-8 weeks |
| Cycle Off | 4 weeks |
GHRP-6 causes significant appetite stimulation — often dosed 15-30 min before meals for bulking protocols. Less recommended for cutting phases. Fasted state improves GH response but conflicts with appetite-driven eating.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Subcutaneous Injection High
Primary route; potent appetite stimulation within 20-30 minutes of injection is expected
Intramuscular Injection High
Occasionally used; similar GH response; faster onset
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving GHRP-6:
Bulking GH Stack
GH-driven muscle growth with strong appetite stimulation for caloric surplus
GHRP-6's appetite-stimulating effect supports caloric surplus in bulking protocols; combined with CJC-1295 for sustained GH elevation.
Healing + GH Stack
Injury recovery with enhanced GH-mediated anabolism
GHRP-6 adds GH-axis support to the classic BPC-157/TB-500 healing stack; best for injuries during bulking phases.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 5mg, 10mg |
|---|---|
| BAC Water | 2ml per 5mg vial |
| Storage | Refrigerate at 2-8°C after reconstitution |
| Shelf Life | 28 days refrigerated |
Need exact syringe measurements?
Amino Acid Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Side Effects & Safety
- Strong appetite stimulation (significant increase in food intake)
- Cortisol and prolactin elevation
- Water retention
- Fatigue or lethargy
- Numbness or tingling
- Potential tachyphylaxis with continuous use
Synergistic Compounds
The following compounds have been studied alongside GHRP-6 for potential complementary or synergistic effects:
Learn More
References & Further Reading
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