GHRP-6
Also known as: Growth Hormone Releasing Peptide-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Overview
GHRP-6 was one of the first synthetic growth hormone secretagogues discovered, derived from the structure of the endogenous opioid peptide met-enkephalin. It is a hexapeptide that acts as a potent ghrelin receptor agonist. Unlike ipamorelin, GHRP-6 stimulates both GH release and prolactin and cortisol to a moderate degree, and is known for strong appetite stimulation. It also shows cardioprotective properties through mechanisms partially distinct from GH release.
Mechanism of Action
GHRP-6 binds to GHS-R1a receptors in the pituitary and hypothalamus, stimulating GH secretion via the phospholipase C/PKC signaling pathway. It also activates GHRH neurons in the hypothalamus, augmenting the GHRH-driven component of GH release. Cardiac protective effects appear to involve sympathetic-to-parasympathetic switching and possible interactions with CD36 receptors in cardiac tissue. GHRP-6 may stimulate GH secretion up to 181-fold above baseline in some studies.
Potential Benefits
- Potent GH secretagogue with up to 181-fold GH increase in some studies
- Muscle hypertrophy support via GH/IGF-1 axis
- Cardioprotective effects through neuromodulation
- Appetite stimulation beneficial for muscle building protocols
- Anti-inflammatory properties in some models
- Enhanced wound healing at sub-GH secretagogue doses
Dosage Protocols
The following reflects doses used in published research studies. This is not medical advice. Consult a qualified healthcare professional.
| Typical Range | 100-300 mcg/dose, 2-3x/day |
| Beginner | 100 mcg once daily at bedtime |
| Intermediate | 200 mcg 2x/day |
| Advanced | 300 mcg 3x/day |
| Cycle Duration | 6-8 weeks |
| Cycle Off | 4 weeks |
GHRP-6 causes significant appetite stimulation — often dosed 15-30 min before meals for bulking protocols. Less recommended for cutting phases. Fasted state improves GH response but conflicts with appetite-driven eating.
Use our Reconstitution Calculator to determine exact syringe units for your protocol.
Routes of Administration
Subcutaneous Injection High — rapid GH and ghrelin-mimetic effects
Standard method. Typical dose 100–300 mcg, 2–3x daily on empty stomach. Strong appetite stimulation within 20 minutes.
Read our full Routes of Administration Guide for detailed comparison of all delivery methods.
Stacking Protocols
Popular research stacks involving GHRP-6:
Mass Gain Stack
Strong GH elevation with appetite stimulation for mass gain phases. GHRP-6's potent ghrelin-mimetic appetite drive plus CJC-1295's sustained GHRH signaling. 100 mcg each, 2–3x daily.
Recovery & Growth Stack
GH-driven recovery protocol. GHRP-6/CJC-1295 maximize GH pulses while BPC-157 accelerates tendon and soft tissue repair. Ideal for athletes in heavy training phases.
Explore our complete Peptide Stacking Guide for more combinations and safety considerations.
Reconstitution
| Typical Vial Size | 5mg, 10mg |
|---|---|
| BAC Water | 2ml per 5mg vial |
| Storage | Refrigerate at 2-8°C after reconstitution |
| Shelf Life | 28 days refrigerated |
Need exact syringe measurements?
Amino Acid Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Side Effects & Safety
- Strong appetite stimulation (significant increase in food intake)
- Cortisol and prolactin elevation
- Water retention
- Fatigue or lethargy
- Numbness or tingling
- Potential tachyphylaxis with continuous use
Safety & Contraindications
This information is for educational purposes only. Consult a qualified healthcare provider before using any peptide.
Active Malignancy
Uncontrolled Diabetes Mellitus
Severe Cardiac Disease
Pregnancy / Lactation
Bleeding Disorders
Active Skin Infection at Injection Site
Drug Interactions
- Insulin / Oral Hypoglycemics:
FDA Safety Information
FDA Category 2 concerns: immunogenicity, cortisol effects, decreased insulin sensitivity.
Pharmacokinetics
| Half-Life | ~15-60 minutes |
|---|---|
| Storage | Store lyophilized peptide at -20°C (long-term) or 2-8°C (short-term, under 30 days). Reconstituted: refrigerate at 2-8°C and use within 28-30 days. Protect from light. Do not freeze reconstituted solution. |
Synergistic Compounds
The following compounds have been studied alongside GHRP-6 for potential complementary or synergistic effects:
Learn More
References & Further Reading
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