Overview
Kisspeptin-10 (KP-10) is the shortest biologically active form of kisspeptin, corresponding to the last 10 amino acids of the KISS1 gene product. While less potent than KP-54 for LH secretion, it is useful for research and reproductive interventions. Emerging research suggests kisspeptin peptides including KP-10 may have applications in sexual dysfunction beyond fertility — it activates the same GnRH-LH axis that mediates sexual arousal, and research is exploring its potential as a treatment for hypoactive sexual desire and psychosexual dysfunction.
Mechanism of Action
KP-10 binds KISS1R (GPR54) on hypothalamic GnRH neurons, activating Gq/11-coupled phospholipase C signaling to drive pulsatile GnRH release. This triggers LH and FSH secretion from the pituitary, driving gonadal steroid production. Studies also suggest direct effects on limbic regions involved in sexual desire, potentially explaining its role in psychosexual function beyond reproductive hormone effects.
Potential Benefits
- Stimulation of pulsatile LH and FSH secretion
- Potential fertility restoration in hypogonadotropic hypogonadism
- Emerging evidence for sexual desire enhancement
- Shorter half-life than KP-54 allowing precise research protocols
- Activates reproductive axis acutely for clinical testing
Research Dosage Notes
The following reflects doses used in published research studies. This is not medical advice.
Clinical studies: IV bolus infusions at defined nmol/kg doses for reproductive axis testing. Not established for therapeutic use.
Amino Acid Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Side Effects & Safety
- Generally well-tolerated in clinical studies
- Hot flashes at higher doses
- Nausea at high doses
- Transient LH surge effects
Synergistic Compounds
The following compounds have been studied alongside Kisspeptin-10 for potential complementary or synergistic effects:
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References & Further Reading
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