Thymalfasin (Thymosin Alpha-1 Clinical)

Also known as: Zadaxin, Tα1, SCV-07

Immune SupportAnti-Aging & Longevity

Overview

Thymalfasin is the pharmaceutical-grade, synthetic form of thymosin alpha-1 (Tα1), marketed under the brand name Zadaxin. It is approved in over 37 countries for treatment of chronic hepatitis B, chronic hepatitis C, and as an adjuvant in cancer immunotherapy. During the COVID-19 pandemic, thymalfasin was used in China and other countries with evidence of mortality reduction in severe cases. Unlike conventional immunostimulants, thymalfasin acts as an immune modulator—normalizing immune function in states of both immunodeficiency and autoimmune dysregulation.

Mechanism of Action

Thymalfasin promotes maturation and differentiation of T-lymphocytes from bone marrow precursors through thymic processing. It activates dendritic cell function, enhances natural killer cell cytotoxicity, stimulates interferon-alpha and interferon-gamma production, and upregulates MHC class I and II expression on antigen-presenting cells. In viral infections, it restores T-cell-mediated antiviral immunity that becomes exhausted or suppressed during chronic infection. IL-2 and IL-3 upregulation contribute to T-helper cell restoration.

Potential Benefits

  • Approved treatment for chronic hepatitis B and C
  • Adjuvant immunotherapy in cancer patients
  • Restored T-cell function in immunocompromised patients
  • Reduced mortality in severe COVID-19 (clinical data from China)
  • Vaccine adjuvant activity
  • Immune normalization in aging (immunosenescence)

Research Dosage Notes

The following reflects doses used in published research studies. This is not medical advice.

Approved dosing: 1.6 mg subcutaneous twice weekly for 6 months (hepatitis B). Cancer adjuvant: 1.6 mg twice weekly alongside chemotherapy.

Amino Acid Sequence

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Side Effects & Safety

  • Generally very well tolerated
  • Rare injection site reactions
  • Mild flu-like symptoms
  • Theoretical immune overstimulation in autoimmune conditions

Synergistic Compounds

The following compounds have been studied alongside Thymalfasin (Thymosin Alpha-1 Clinical) for potential complementary or synergistic effects:

Interferon-alphaAntiviral agentsEpithalonVilon

Learn More

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References & Further Reading

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